Senior Director, Global Medical Affairs

Overview

Serve as Global Medical Affairs Lead for Centessa's lead orexin receptor 2 agonist program (cleminorexton), setting and executing global medical strategy across the product lifecycle with a focus on launch readiness, scientific leadership, evidence generation, external engagement and cross-functional partnership.

What you'll do

• Lead the global medical affairs strategy and tactical execution plan for cleminorexton.
• Serve as Global Medical Affairs Lead and core member of the cross-functional asset team.
• Ensure alignment of medical strategy with corporate objectives, clinical development milestones and commercialization plans.
• Establish long-range medical affairs planning to support regulatory approvals, launch readiness and lifecycle management.
• Identify emerging scientific opportunities, evidence gaps and stakeholder needs to inform future development.
• Lead medical launch preparedness activities across major global markets.
• Partner with commercial, market access, HEOR, regulatory affairs and regional medical teams to develop integrated launch strategies.
• Collaborate with medical affairs colleagues to align deliverables with strategy and launch timelines, including scientific platforms, training content, medical information resources, publications, congress activities and insights generation.
• Support pre-launch and launch planning, including collaborating with HEOR and market access on global payer engagement strategies and value communication.
• Build and maintain relationships with global key opinion leaders, investigators, professional societies and patient advocacy organizations.
• Lead scientific advisory boards, expert consultations and other insight-gathering initiatives.
• Represent Centessa at major scientific congresses and industry meetings.
• Serve as a credible scientific ambassador and subject matter expert for orexin biology and sleep-wake disorders.
• Act as a strategic partner to commercial, market access, HEOR, regulatory, clinical development, patient advocacy and corporate affairs.
• Contribute medical expertise to brand strategy, payer engagement, disease-state education and scientific communication initiatives.
• Serve as strategic partner for development of scientific platforms, publication strategies, educational programs and medical training.
• Provide medical review and guidance for externally facing scientific materials in compliance with applicable regulations and company policies.

What you'll need

• Advanced scientific or clinical degree (MD, PharmD or PhD).
• Minimum 10 years of Medical Affairs leadership experience.
• Demonstrated experience leading at least one successful global product launch.
• Experience serving as a global medical lead for late-stage development or commercial products.
• Strong understanding of global medical affairs, evidence generation, payer evidence requirements and commercialization readiness.
• Proven ability to drive strategy in a matrix environment.
• Proven track record of collaborating closely with commercial, market access, HEOR, regulatory affairs and clinical development organizations.
• Exceptional communication, presentation and stakeholder management skills.

Nice to have

• 5 years of global medical affairs experience.
• Experience in neuroscience, sleep medicine, neurology, psychiatry or rare disease.
• Experience launching products in North America, Europe and Asia-Pacific markets.

Details

• Remote, based in the US.
• Occasional travel (~20%).
• Reports to the Head of Medical Affairs.
• Anticipated wage $177,000 - $338,800; full-time employees eligible for company bonus.