Principal Scientist

Overview

Principal Scientist to help deliver translational medicine research services for biopharmaceutical clients, primarily in the Immuno-Oncology and autoimmune/inflammatory space, including design and development of qualified and validated immunophenotyping and antigen-specific cell-based assays, and to train and mentor junior scientists and team members.

What you'll do

• Provide mentoring, coaching and team leadership to Flow Laboratory team members, hold one-on-one engagement meetings with direct reports, set goals, conduct performance reviews and set priorities for lab work.
• Motivate the team, share knowledge on FACS, participate in recruitment process and revenue forecasting.
• Design and implement cell-based assays to meet client requirements, which may include complex flow immunophenotyping assays and primary cell based assays.
• Write and implement standard operating procedures (SOPs) to perform assays to meet client requirements and the level of regulatory compliance needed.
• Utilize current SOPs to perform cell assays such as flow immunophenotyping, ELISpot, and other custom cell based assays.
• Generate technical reports and other communications required to present data to clients.
• Write posters and papers for submission to conference organizers and peer reviewed journals, and write reviews and white papers.
• On occasion, review and edit client proposals, contracts and proposals as appropriate.
• Train scientific staff in the review and presentation of data, including client reports, posters and papers for peer reviewed journals.
• Train technical staff how to perform laboratory procedures, and devise and perform validation schema to ensure staff are superbly trained and competent.
• Maintain and support safe lab practices and environment.
• Track and trend laboratory efficiency and quality.
• Perform duties with high degree of independence, quality, and efficiency.
• Act as internal expert on technical advances and industry trends, anticipate and act as a thought leader to management on all matters of major importance, initiate and/or recommend appropriate courses of action, and identify matters requiring policy interpretation or revision.
• Promote the company to local, regional, national, and international constituencies through networking, speaking engagements, activity in professional associations and publications.

What you'll need

• Must have a Ph.D. in life sciences or relevant field (preferably Immunology, Cellular Biology).
• At least 8 years of full-time post-doctoral laboratory experience.
• Strong bench scientist skills around cell-based assays.
• Hands-on flow cytometry experience.
• Core competencies of standard biology laboratory experience, e.g. cell isolation, and primary cell based assays.
• Experience with cell sorting, trouble-shooting and client relationships, alliance partnerships and timelines.
• Experience in validation/qualification of assays to CAP/CLIA/GLP or ISO guidelines.
• Strong organizational skills.
• Strong communication skills.
• Experienced technical report generation.
• The ability to see and differentiate between colors on the full color spectrum.
• Ability to lift and carry between 1-15 lbs.; ability to lift up to 50 lbs. overhead with assistance; frequently required to sit, grasp, and use right/left finger dexterity.
• May be exposed to a cold freezer environment (freezer temperatures range between -20ºC and -196ºC).
• Must be able to read, write, speak fluently and comprehend the English language.

Nice to have

• Preferably experience with ELISpot and other cell based assays.
• Preferred 10-15+ years' experience as CORE lab member with leadership role as direct manager to flow cytometry team.
• Industrial experience and/or management of outside collaborations is desirable.
• Experience with viral infections; cell culture and cell line derivation; nucleic acid (RNA & DNA) extraction from primary human samples; nucleic acid characterization by spectrophotometer, Agilent, and fluorescence-based detection.

Details

• Location: Bangalore, Karnataka, India.
• Candidates must be legally authorized to work in the country of employment without employer sponsorship.