Research Scientist - AD

Overview

Senior Research Scientist role focused on preparative HPLC purification of APIs, intermediates, impurities, degradants, metabolites and synthetic target compounds in a pharmaceutical CDMO setting.

What you'll do

• Perform reverse phase preparative HPLC purification of APIs, intermediates, impurities, degradants, metabolites, and synthetic target compounds.
• Develop and optimize purification methods using C18, C8, Phenyl, Biphenyl, and specialty stationary phases.
• Execute preparative purifications ranging from milligram to multi-gram scale.
• Design and implement purification strategies for challenging compounds with poor solubility, low stability, or complex impurity profiles.
• Maximize purity, recovery, and productivity while maintaining project timelines.
• Transfer analytical HPLC/UPLC methods to preparative scale.
• Optimize mobile phase composition, pH, buffers, gradients, flow rates, and loading conditions.
• Conduct loading studies and purification scale-up activities.
• Improve chromatographic resolution and recovery through systematic method optimization.
• Operate and maintain preparative HPLC systems, fraction collectors, and associated software, including Waters, Agilent, Shimadzu, Gilson, Biotage, or equivalent platforms.
• Perform routine troubleshooting of chromatographic systems and columns.
• Maintain instrument utilization, calibration, and documentation records.
• Analyze collected fractions using analytical HPLC/UPLC, LC-MS, and NMR techniques.
• Interpret chromatographic and spectroscopic data to confirm compound identity and purity.
• Support impurity identification and structural characterization activities.
• Generate purification reports and technical summaries.
• Support pharmaceutical R&D, process development, impurity isolation, forced degradation, and reference standard projects.
• Collaborate with synthetic chemistry, analytical, formulation, and regulatory teams.
• Prioritize multiple projects and ensure timely delivery of purified compounds.
• Participate in client discussions and provide technical recommendations.

Details

• Location: Ahmedabad, Gujarat, India.