Principal Scientist / Senior Principal Scientist - Peptide Synthesis

Overview

Build and lead a new peptide synthesis group from the ground up, starting hands-on at the bench and moving toward leadership as the team matures.

What you'll do

• Set up the peptide synthesis lab and define synthesis, purification and QC standards.
• Synthesise linear, cyclic, lipidated and modified peptides by Fmoc SPPS (manual, microwave and automated), including orthogonal on-resin chemistry for branching and cyclisation.
• Troubleshoot difficult sequences (aggregation, racemisation, aspartimide formation) and give the design team early feedback on synthetic feasibility.
• Guide preparative RP-HPLC purification, interpret HPLC and LC-MS data, and decide between re-purification, re-synthesis and release.
• Specify and qualify synthesisers and lyophilisers, write SOPs, and partner with CROs/CDMOs for scale-up.
• Hire, train and mentor 3-4 chemists; plan workloads, run technical reviews and build a strong safety culture.

Details

• Location: Genome Valley, Hyderabad, India.
• Employment type: Full-Time.